Welcome to the Li Lab

Our research aims at understanding the physical and structural basis of biological processes. Using nuclear magnetic resonance (NMR) spectroscopy, we capture a variety of dynamic processes in biomacromolecules. The time scales of these processes are wide-ranging and often coincide with the time scales of functionally important biological events. One of the main areas of focus is the signal transduction pathways involved in cancers and autoimmune diseases. We are particularly interested in understanding how the structural and functional properties of signaling proteins are modulated by post-translational modifications, such as ubiquitylation and phosphorylation, and defining the relationship between changes in physical properties and functional properties of proteins. Elucidation of the basic molecular mechanisms underlying biological phenomena has a wide variety of applications such as rationally designing small molecule inhibitors, and optimization of protein molecules for use as therapeutic agents and biocatalysts in industrial processes.

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